Multivitamin Treatment | A Retinol Hyaluronic Acid Serum

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The Science of Gentle Transformation: Visible Results Without Irritation

When it comes to truly effective skincare, the evidence speaks for itself. After years of research and personal experience with sensitive skin, I've created what sensitive skin has been waiting for: a retinol serum that delivers powerful results without the typical irritation.

The Multivitamin Treatment isn't just another retinol product—it's a scientifically formulated serum that combines encapsulated retinol with hyaluronic acid and a precise blend of skin-nourishing vitamins to transform your complexion while respecting your skin's delicate balance.

Why Most Retinol Products Fall Short

If you've tried retinol before, you might have experienced the frustrating trade-off: visible results that come with redness, flaking, and irritation. Many brands suggest Bakuchiol as a gentler alternative, but the research simply doesn't support its efficacy compared to decades of studies backing retinol.

The problem isn't retinol itself—it's how it's formulated and delivered to your skin.

Most retinol products fail in three critical ways:

  1. They use unstable forms of retinol that degrade quickly
  2. They don't provide adequate hydration to counteract dryness
  3. They lack complementary ingredients that enhance benefits while minimizing irritation

The Multivitamin Treatment addresses all three issues through innovative formulation science.

The Breakthrough: Encapsulated Retinol + Hyaluronic Acid

At the heart of this serum is encapsulated retinol—a technological advancement that protects the retinol molecule until it penetrates your skin. This means:

  • Greater stability: The retinol remains potent and effective longer
  • Controlled release: Gradual delivery that minimizes irritation
  • Enhanced penetration: More retinol reaches the deeper layers where it's needed
    most

But the real magic happens when this encapsulated retinol works in synergy with hyaluronic acid. This powerful humectant:

  • Draws moisture to your skin (holding up to 1,000 times its weight in water)
  • Creates a hydration cushion that reduces potential irritation
  • Plumps skin cells to immediately diminish the appearance of fine lines
  • Enhances the skin's barrier function while retinol works beneath the surface

A Complete Vitamin System for Your Skin

Your skin, like your body, thrives on proper nutrition. The Multivitamin Treatment delivers a comprehensive blend of skin-essential vitamins:

  • Vitamin A (Retinol): Promotes cell turnover and collagen production for smoother, firmer skin
  • Vitamin B3 (Niacinamide): Strengthens skin barrier function and reduces the appearance of pores
  • Vitamin C (Sodium Ascorbyl Phosphate & Ascorbyl Glucoside): Brightens skin tone and provides antioxidant protection
  • Pro-Vitamin B5 (Panthenol): Soothes skin and supports healing processes

This multivitamin approach means your skin isn't just receiving one benefit—it's getting complete nourishment for comprehensive rejuvenation.

Botanical Intelligence for Sensitive Skin

Beyond vitamins, the Multivitamin Treatment harnesses the power of carefully selected botanical extracts that work in harmony with your skin:

  • Turmeric Water: Calms the appearance of redness and neutralizes free radicals
  • Centella Asiatica (Hydrocotyl): Supports skin's natural renewal and collagen production
  • Cucumber Extract: Provides cooling relief and natural hydration
  • Chamomile Extract: Soothes the look of irritation and redness
  • Willow Bark Extract: Naturally exfoliates and helps clear congestion

Each botanical is chosen not just for its individual benefits, but for how it complements the active ingredients to enhance results while maintaining comfort.

Visible Transformation Without Compromise

The Multivitamin Treatment delivers what other retinol products only promise: 

  • Smoother skin texture with longterm use
  • Diminished appearance of fine lines and wrinkles
  • More even skin tone with reduced dark spots
  • Refined pores and less congestion
  • Increased radiance and natural glow
  • Long-term skin resilience and health

All this without the typical retinol adjustment period of excessive dryness, redness, and irritation.

Perfect For:

  • Sensitive skin that hasn't tolerated retinol in the past
  • First-time retinol users looking to start with a gentle yet effective formula
  • Experienced retinol users seeking better results with less irritation
  • Aging skin concerned with fine lines, wrinkles, and loss of firmness
  • Dull complexions needing renewal and radiance
  • Congested skin that requires clearing without harshness

The Gentle Introduction Method

While the Multivitamin Treatment is formulated for minimal irritation, I recommend a gradual introduction to ensure your skin adjusts comfortably:

  • First month: Apply once weekly, after your hydration and moisturizer steps
  • Second month: Increase to twice weekly applications
  • Maintenance: Continue with 2-3 applications weekly for optimal results

This measured approach allows your skin to build tolerance while still experiencing transformative benefits.

How to Use:

  • Always patch test before first use
  • Use at night only, maximum 3 times a week
  • Apply to clean, dry skin
  • Gently massage 1-2 pumps onto face and neck until fully absorbed
  • Follow with moisturizer if desired
  • Always use sunscreen during daytime hours

A Note from Amy, Founder of YOU Skincare:

I created this serum after years of struggling with my own sensitive skin. Like many of you, I wanted the proven benefits of retinol without the irritation. As a scientist and formulator, I knew there had to be a better way—and after countless iterations, the Multivitamin Treatment was born. This isn't just another product in my line; it's the solution I personally needed and couldn't find elsewhere. I'm proud to share it with you, and I can't wait for you to experience what truly gentle, effective skincare feels like.

Are you ready to transform your skin without compromise?

Note: If you're pregnant or breastfeeding, please consult with your doctor before using products containing retinol.

IngredientsAqua (Water), Aloe Barbadensis Juice, Curcuma longa (Turmeric) Water, Beta Glucan, Glycerin, Sodium Ascorbyl Phosphate, Propanediol, Niacinamide, Ascorbyl Glucoside, Hydrocotyl (Centella Asiatica) Extract, Arctostaphylos Uva Ursi Leaf Extract, Cucumis Sativus (Cucumber) Fruit Extract,  Chamomilla Recutita (Matricaria) Flower Extract, Salix Nigra (Willow) Bark Extract, Hydroxyethyl Acrylate / Sodium Acryloyldimethyl Taurate Copolymer, Sodium Hyaluronate, Retinol, Lecithin, Potassium Phosphate, Hydroxyethylcellulose, Pentylene Glycol, Sodium Citrate, Xanthan Gum, Dehydroacetic Acid, Benzyl Alcohol, Sodium Glutonate, Polysorbate 20, Alcohol, Potassium sorbate.

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05/19/2025
ginger t.
United States
I bought this on a whim after having a bad reaction to a product and this being on my "to try" list for awhile. This serum is perfect for my combo skin that's prone to congestion. The turn-around to smooth, healthy looking skin was much faster than I anticipated and I'll definitely be repurchasing!
Clarifying Glow Serum | Dark Spot Correcting Glow Serum for Radiant, Even-Toned Skin
05/19/2025
ginger t.
United States
I have combo/oily skin and heading into summer this is the perfect first step to keep my skin hydrated but not feeling heavy or greasy.
Moisture Replenishing Essence | Hydrating Essence for Plump, Dewy, and Rejuvenated Skin
12/12/2024
Hibaq H.
United States
Easy application, not sticky, non-irritating, absorbs fast, and doesn't have that orange tint as the other serums do. It works well with my daily moisturizer and sunscreen. I’m so happy with this product!!! :)
Vitamin C Antioxidant Serum
08/01/2024
Ashley
United States
I live in a very dry climate. I prefer to use Amy's hydration serum at night while I run the humidity. The combination helps perk up my dehydrated skin caused by a damaged barrier. When my barrier is intact I am able to use this serum AM and PM. Regardless how dry the climate is. Very hydrating and...I live in a very dry climate. I prefer to use Amy's hydration serum at night while I run the humidity. The combination helps perk up my dehydrated skin caused by a damaged barrier. When my barrier is intact I am able to use this serum AM and PM. Regardless how dry the climate is. Very hydrating and helping me repair my barrier.
Essential Hydration Serum
08/01/2024
Ashley
United States
I comprised my barrier 8 yrs ago and Amy was amazing and helped me tremendously. At the time glow was the only thing I could put on my skin without my skin freaking out. Fast forward to present day. I took a small break from Glow (regretfully), and broke out from antibiotics and products that...I comprised my barrier 8 yrs ago and Amy was amazing and helped me tremendously. At the time glow was the only thing I could put on my skin without my skin freaking out. Fast forward to present day. I took a small break from Glow (regretfully), and broke out from antibiotics and products that didn't suit my reactive skin. I thought the answer was chemical exfoliants. Boy was I wrong. My skin became reactive, oily, scaly/rough almost like another layer of skin was resting on top. I reached out to Amy and she was happy to help me. She assured me even the most reactive/sensitive skin can handle Glow. She was right. I have been using glow for a wk! AM and PM and the inflammation in my skin is getting better by the day. I am forever grateful for Amy and her Glow.
Clarifying Glow Serum
07/24/2024
Dalia E.
Canada
This is a holy grail product for me that I have been using for years and can vouch for its consistency and incredible results. However the shipping logistics are prohibitive and make it really hard to continue ordering. I am in Toronto and even though I pay premium for shipping, I have to pay...This is a holy grail product for me that I have been using for years and can vouch for its consistency and incredible results. However the shipping logistics are prohibitive and make it really hard to continue ordering. I am in Toronto and even though I pay premium for shipping, I have to pay almost the price of a full bottle in customs. The total adds up to two bottles of product from other luxury brands. Don’t get me wrong, the product itself is worth but the cost of shipping and customs to Canada isn’t. I won’t be repurchasing until a better deal is offered to Canadian customers.
Clarifying Glow Serum
03/25/2024
Vaishali
United States
Loved the shade and feeling of the Hydra Lipstick . My lips Never felt so good before.
HydraLip Stick
03/25/2024
Vaishali
United States
This new Hydra Lip stick is much awaited product by YouSkincare. I just loved it. I tried with the YouSkincare lip balm followed by new Lipstick. Results are amazing. It’s really long lasting without stickiness. It keeps my lips well hydrated even in this cold temperatures of Minnesota. A must try...This new Hydra Lip stick is much awaited product by YouSkincare. I just loved it. I tried with the YouSkincare lip balm followed by new Lipstick. Results are amazing. It’s really long lasting without stickiness. It keeps my lips well hydrated even in this cold temperatures of Minnesota. A must try one more product of YouSkincare😇
HydraLip Stick
03/24/2024
Hibaq H.
United States
The best HydraLip Stick I ever had!!! Beautiful color and comfortable, moisturizing lipstick. Hope this color doesn't discontinue because I will not look for any brand. Thanks , Amy :)
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02/13/2024
kimberly
United States
A must have for dehydrated skin!
Essential Hydration Serum
07/07/2023
Rachael R.
United States
I truly cannot live without this sublime lip whip… it is the ONLY lip product I am able to use. Everything else does not last as long or does not moisturize as deeply. I love that it is unscented. It is rich but absorbs beautifully, a testament to Amy’s skills as a formula queen. My only quibble? I...I truly cannot live without this sublime lip whip… it is the ONLY lip product I am able to use. Everything else does not last as long or does not moisturize as deeply. I love that it is unscented. It is rich but absorbs beautifully, a testament to Amy’s skills as a formula queen. My only quibble? I wish it were bigger! This little pot lasts for two months for me with very generous applications three to six times a day. (I use it after each time I brush my teeth.)
Lip Whip
03/28/2022
Rachael R.
United States
I have quite oily skin and I had actually stopped using moisturizers before trying this. Amy kindly included a sample of this with one of my orders. Even though it is rich and rather thick, it hasn’t caused any acne and has actually toned down my oiliness! My skin is very soothed with this and I...I have quite oily skin and I had actually stopped using moisturizers before trying this. Amy kindly included a sample of this with one of my orders. Even though it is rich and rather thick, it hasn’t caused any acne and has actually toned down my oiliness! My skin is very soothed with this and I notice redness has decreased. I actually feel like my skin is more resilient with this… so much so that I started using prescription tretinoin again and thanks to this moisturizer and the Essence, my skin hasn’t suffered irritation as it gets used to the tretinoin. I am amazed by this formulation, so rich yet not greasy or clogging… soothing and strengthening… unscented. It is a Hero product!
Daily Repair Moisturizer
03/28/2022
Rachael R.
United States
This is the very best lip balm my extremely dry lips have ever used! I can start wearing lipstick again thanks to this product… my lips were so dry I couldn’t tolerate anything except regular applications of lip balm every couple of hours. I love that this product doesn’t cause any breakouts on my...This is the very best lip balm my extremely dry lips have ever used! I can start wearing lipstick again thanks to this product… my lips were so dry I couldn’t tolerate anything except regular applications of lip balm every couple of hours. I love that this product doesn’t cause any breakouts on my facial skin when I apply a thick layer. I used to wake up in the middle of the night needing to reapply lip balm… but this product works for a good 12 plus hours with no need for reapplication. I appreciate that this is unscented. It is so soothing and moisturizing… this is my Holy Grail lip balm.
Lip Whip
03/24/2022
Rachael R.
United States
I love the sensation of a mist or an essence, but haven’t found any product that really made a difference in my skin… until this. I’m amazed how soothed and hydrated my skin is after just one or two pumps of this… it is truly weightless on my oily skin, yet tones down redness considerably. I find I...I love the sensation of a mist or an essence, but haven’t found any product that really made a difference in my skin… until this. I’m amazed how soothed and hydrated my skin is after just one or two pumps of this… it is truly weightless on my oily skin, yet tones down redness considerably. I find I can use less serum and moisturizer after this. I need to purchase backups of this. It really makes a difference in my skin and, like another reviewer observed, takes the sting out of tretinoin. I appreciate that there is practically no scent. My sensitive skin loves this!
Moisture Replenishing Essence
12/13/2021
Tuan P.
United States
One of the best products that I have found in 2021. The owner is very friendly!
Clarifying Glow Serum
10/18/2021
Brandi G.
United States
Why is this so good?? I don’t even know the science behind it. But my face always look more even and plump while using!
Clarifying Glow Serum
07/21/2021
Kelsey M.
United States
Was able to try several products in mini version, which is such a good option for someone with sensitive skin. I’ll be purchasing full size of the moisturizer and Clarity serum!
Minis
04/20/2021
Dalia E.
Canada
This is one product I cannot live without. The glow and clarity it adds to my skin are unreal. The difference is noticed immediately as soon as I stop using it. I can’t remember how many bottles I have purchased but this is always going to be part of my skincare routine.
Clarifying Glow Serum
02/20/2021
Maya R.
United States
I really loved every item in this trial kit! I’ve been hooked on another brand for the last 3 years and nothing I’ve tried has come close. These products in the trial kit are just so good! The textures are so satisfying and my skin is so happy. I live in a dry, windy, and currently freezing...I really loved every item in this trial kit! I’ve been hooked on another brand for the last 3 years and nothing I’ve tried has come close. These products in the trial kit are just so good! The textures are so satisfying and my skin is so happy. I live in a dry, windy, and currently freezing environment and my skin is so calm. My skin has been dry and dehydrated as of late. It doesn’t help that I’m using prescription retinoid but my skin is so comfortable when I use this routine. Sadly, I have run out of my samples and have been forced to use my other skincare and I’m so shocked at how much I miss You Skincare! Unfortunately, I have so many backups of my other brand but it’s not stopping me from repurchasing a few key items from this set! Once I’m done with the rest of my products I will absolutely be replacing them with literally everything here haha
Discovery Kit- Perfect skincare routine on the go!
02/16/2021
Katharine F.
United States
Total love. Hope she brings this back every year. A slight tingle for the first minute, then soft, brightened, smooth skin. Very effective
Chocolate & Roses Brightening Mask *Limited Edition*
02/16/2021
Katharine F.
United States
Exfoliating beads are gentle. Formula is amazing
Congestion Clearing Enzyme Mask
01/15/2021
Brytt G.
United States
Goes on so nice, leave behind a nourishing glow. Smells amazing. Really a great general purpose serum.
Clarifying Glow Serum
01/10/2021
Anonymous
United States
Two new products and one holy grail favorite! What’s not to love? I took a slight chance ordering this set with no reviews and before it was even announced by email. But it was only the very slightest of chances because I trust Amy and virtually always love everything she creates. The mist is light...Two new products and one holy grail favorite! What’s not to love? I took a slight chance ordering this set with no reviews and before it was even announced by email. But it was only the very slightest of chances because I trust Amy and virtually always love everything she creates. The mist is light and smells faintly herbal. The cleanser is gentle and effective. The clarifying glow serum is amazing. Definitely worth trying in this set if you are considering it because it’s quite a deal for three full-sized products. 😍
Box of Gratitude
12/31/2020
Anonymous
United States
I love this cleanser and have now repurchased this to continue using it. It smells delicious and is gentle and my skin feels clean and happy after using it! I love this cleanser because I can use it on wet skin as a second cleanse and it washes away completely and easily with water.
Balancing Cleansing Milk
12/24/2020
Charles A.
United States
I’ve used this flash mask a bit and I’ve enjoyed using it each time. I’m still playing with proportions and how it fits in with the rest of my masking and skincare regime. But overall I feel that I only need a small amount to apply. I really do like the very gentle manual exfoliation that the...I’ve used this flash mask a bit and I’ve enjoyed using it each time. I’m still playing with proportions and how it fits in with the rest of my masking and skincare regime. But overall I feel that I only need a small amount to apply. I really do like the very gentle manual exfoliation that the jojoba beads provide. I do also like the tactile experience of applying this given that there are the beads in the mask. Each time I use this there is a bit of tingling but there has not been any discomfort. I’m actually quite amazed by this mask because from just the INCI I had no idea how effective it would be or how enjoyable it would be. I purchased this mask based on the recommendations that I saw from bloggers like SkincarmaNYC and The Beauty Endeavor, and they were right. I’m overall impressed by what I’ve tried from YOU.
Congestion Clearing Enzyme Mask
09/24/2020
Vaishali C.
United States
I was so mesmerized when I noticed the difference in my skin tone . I feel healthy skin and it gives me so much confidence about my looks. Big Thank You to YOU Skincare.
Hydration Duo!
07/22/2020
Nurul I.
United States
I have not incorporated a Moisturizer in my skincare routine for years because most other formulations tend to be too heavy and break me out. I’m glad I took the chance and ordered the Daily Repair Moisturizer. It layers beautifully on top of the other serums I purchased from You Skincare and most...I have not incorporated a Moisturizer in my skincare routine for years because most other formulations tend to be too heavy and break me out. I’m glad I took the chance and ordered the Daily Repair Moisturizer. It layers beautifully on top of the other serums I purchased from You Skincare and most importantly, it moisturizes without clogging pores or causing any breakouts. I have dry skin, so I mix a drop or two of my favorite facial oil into this Moisturizer and it is perfect! My husband uses this too, he has normal skin and finds it just right. It is not too heavy at all. Would definitely repurchase when we run out.
Daily Repair Moisturizer
07/17/2020
Colby H.
United States
I adore Amy’s Clarifying Glow Serum. I’ve used it for years, and will continue to repurchase again and again because it is that effective! It plays well with all other products in my regime, although it is what I notice makes the biggest difference in my skin. I also love that I’m supporting a...I adore Amy’s Clarifying Glow Serum. I’ve used it for years, and will continue to repurchase again and again because it is that effective! It plays well with all other products in my regime, although it is what I notice makes the biggest difference in my skin. I also love that I’m supporting a small business, and a wonderful person!
Clarifying Glow Serum
07/13/2020
Kristy B.
United States
I have always had acne with varying levels of manageability. For the last six months or so I have been having the worst hormonal breakouts and my skin was in the worst condition it had been in since my mid-teens. I am now 39 and had to begin medication for hypothyroid and low estrogen. My skin went...I have always had acne with varying levels of manageability. For the last six months or so I have been having the worst hormonal breakouts and my skin was in the worst condition it had been in since my mid-teens. I am now 39 and had to begin medication for hypothyroid and low estrogen. My skin went absolutely crazy. After months of dermatologist visits and various prescription treatments the breakouts have slowed but my skin is now a strange combination of oily with dry, flaky patches. I purchased this serum a few weeks ago to try to start normalizing things again. It has done an excellent job or starting to add some glow back into my skin while quickly drying out the smaller whiteheads that pop up. I am very pleased.
Clarifying Glow Serum
07/10/2020
Van D.
United States
My skin has been feeling dry and dehydrated lately and the products in this set is like a fresh drink of water for my skin! Both products have now become an essential part of my skincare, keeping my face comfortable and hydrated without being too heavy or aggravating any breakouts. Amazing...My skin has been feeling dry and dehydrated lately and the products in this set is like a fresh drink of water for my skin! Both products have now become an essential part of my skincare, keeping my face comfortable and hydrated without being too heavy or aggravating any breakouts. Amazing formulation. I am so glad I finally tried You Skincare.
Hydration Duo!
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